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A multiscale material model for heterogeneous liquid droplets in solid soft composites

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 5,   Pages 1292-1299 doi: 10.1007/s11709-021-0771-3

Abstract: In contrary with conventional composites, which are made of solid elastic inclusions, available materialcomposites including liquid droplets are for highly idealized configurations and do not include all materialavailable models for liquid droplets in solid soft composites and presents a multiscale computational materialDifferent micromechanical material models are incorporated into the presented computational framework

Keywords： liquid in solid     soft composite     computational modeling     multiscale model     heterogeneity    

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Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune    

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Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and

Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 551-561 doi: 10.1007/s11684-020-0760-2

Abstract: Several studies correlated tumor recurrence with tumor heterogeneity and the immune microenvironment.this review, we introduce the different mechanisms involved in glioma progression, including tumor heterogeneity

Keywords： glioma     evolution mechanism     strategies     tumor heterogeneity     secondary glioma    

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Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype

Xu Chen, Xiaomao Xu, Fei Xiao

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 425-432 doi: 10.1007/s11684-013-0295-x

Abstract: This review briefly describes the heterogeneity of COPD, with focus on recent advances in the correlations

Keywords： chronic obstructive pulmonary disease     heterogeneity     phenotype     genotype     prediction    

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Selectively structural fractionation and economical-functionality conversion of lignocellulosic biomass

Chen Hongzhang,Qiu Weihua and Wang Lan

Strategic Study of CAE 2014, Volume 16, Issue 3,   Pages 27-36

Abstract: selective- fractionation and economical-functionality”was proposed，based on the recognition of heterogeneityAccording to the association of raw material features，conversion processes and products requirement，diversified

Keywords： biorefining     heterogeneity of raw material     selective-fractionation and economical-functionality     industrialized    

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Computational modeling of fracture in concrete: A review

Luthfi Muhammad Mauludin, Chahmi Oucif

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 3,   Pages 586-598 doi: 10.1007/s11709-020-0573-z

Abstract: The complex material, such as concrete, has been widely used in construction industries and become trendingAs heterogeneity of concrete material is major concern in micromechanical-based concrete modeling, one

Keywords： concrete fracture     macroscopic     micromechanical     heterogeneity    

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Analysis of stress and failure in rock specimens with closed and open flaws on the surface

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 5,   Pages 1222-1237 doi: 10.1007/s11709-021-0773-1

Abstract: The influence of closed and open surface flaws on the stress distribution and failure in rock specimens is investigated. Heterogeneous finite element models are developed to simulate the compression tests on flawed rock specimens. The simulated specimens include those with closed flaws and those with open flaws on the surface. Systematic analyses are conducted to investigate the influences of the flaw inclination, friction coefficient and the confining stress on failure behavior. Numerical results show significant differences in the stress, displacement, and failure behavior of the closed and open flaws when they are subjected to pure compression; however, their behaviors under shear and tensile loads are similar. According to the results, when compression is the dominant mode of stress applied to the flaw surface, an open flaw may play a destressing role in the rock and relocate the stress concentration and failure zones. The presented results in this article suggest that failure at the rock surface may be managed in a favorable manner by fabricating open flaws on the rock surface. The insights gained from this research can be helpful in managing failure at the boundaries of rock structures.

Keywords： surface flaw     heterogeneity     circular hole     numerical modeling     relative displacement    

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Heterogeneous influence of individuals’ behavior on mask efficacy in gathering environments

Frontiers of Engineering Management   Pages 550-562 doi: 10.1007/s42524-022-0193-5

Abstract: The heterogeneity of individuals can cause mask efficacy in a specific gathering environment to be differentFurthermore, the heterogeneity of gathering environments causes the epidemic prevention effect of masksGiven the heterogeneity of individual behavior, if individuals who are more active in terms of interpersonal

Keywords： COVID-19     masks     behavioral heterogeneity     asymptomatic infection    

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Liquid metal material genome: Initiation of a new research track towards discovery of advanced energy

Lei WANG, Jing LIU

Frontiers in Energy 2013, Volume 7, Issue 3,   Pages 317-332 doi: 10.1007/s11708-013-0271-9

Abstract: With many superior physical properties over conventional fluids, the low melting point liquid metal materialInspired by the Material Genome Initiative as issued in 2011 by the United States of America, a morespecific and focused project initiative was proposed in this paper—the liquid metal material genome aimedThe theoretical strategies and experimental methods in the research and development of liquid metal materialParticularly, the calculation of phase diagram (CALPHAD) approach as a highly effective way for material

Keywords： liquid metal material genome     energy material     material discovery     advanced material     room-temperature liquid    

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Robust topology optimization of multi-material lattice structures under material and load uncertainties

Yu-Chin CHAN, Kohei SHINTANI, Wei CHEN

Frontiers of Mechanical Engineering 2019, Volume 14, Issue 2,   Pages 141-152 doi: 10.1007/s11465-019-0531-4

Abstract: Enabled by advancements in multi-material additive manufacturing, lightweight lattice structures consistingThis work proposes a density-based robust topology optimization method for meso- or macro-scale multi-materiallattice structures under any combination of material and load uncertainties.The method utilizes a new generalized material interpolation scheme for an arbitrary number of materialsExamples of a cantilever beam lattice structure under various material and load uncertainty cases exhibit

Keywords： robust topology optimization     lattice structures     multi-material     material uncertainty     load uncertainty    

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State-of-the-Art Review of High-Throughput Statistical Spatial-Mapping Characterization Technology and Its Applications Review

Haizhou Wang, Lei Zhao, Yunhai Jia, Dongling Li, Lixia Yang, Yuhua Lu, Guang Feng, Weihao Wan

Engineering 2020, Volume 6, Issue 6,   Pages 621-636 doi: 10.1016/j.eng.2020.05.005

Abstract: No material is homogeneous or isotropic at a certain small scale.Parts of the material that differ from one another can be termed ‘‘natural chips.” At different spots on the material, the composition, structure, and properties vary slightly,and the combination of these slight differences establishes the overall material performance.applications of high-throughput statistical spatialmapping characterization technology based on the intrinsic heterogeneity

Keywords： Material heterogeneity     High-throughput characterization     Statistical spatial-mapping     Original-position    

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Factors affecting the distribution of microplastics in soils of China

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 9, doi: 10.1007/s11783-023-1710-4

Abstract:

● Microplastic (MP) abundance in soil of China was highly heterogeneous.

Keywords： Microplastic distribution     Microplastic heterogeneity     Effecting factors     Agriculture     Socio-economic    

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Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 240-262 doi: 10.1007/s11684-022-0936-z

Abstract: Detailed characterizations of genomic alterations have not identified subtype-specific vulnerabilities in adult gliomas. Mapping gliomas into developmental programs may uncover new vulnerabilities that are not strictly related to genomic alterations. After identifying conserved gene modules co-expressed with EGFR or PDGFRA (EM or PM), we recently proposed an EM/PM classification scheme for adult gliomas in a histological subtype- and grade-independent manner. By using cohorts of bulk samples, paired primary and recurrent samples, multi-region samples from the same glioma, single-cell RNA-seq samples, and clinical samples, we here demonstrate the temporal and spatial stability of the EM and PM subtypes. The EM and PM subtypes, which progress in a subtype-specific mode, are robustly maintained in paired longitudinal samples. Elevated activities of cell proliferation, genomic instability and microenvironment, rather than subtype switching, mark recurrent gliomas. Within individual gliomas, the EM/PM subtype was preserved across regions and single cells. Malignant cells in the EM and PM gliomas were correlated to neural stem cell and oligodendrocyte progenitor cell compartment, respectively. Thus, while genetic makeup may change during progression and/or within different tumor areas, adult gliomas evolve within a neurodevelopmental framework of the EM and PM molecular subtypes. The dysregulated developmental pathways embedded in these molecular subtypes may contain subtype-specific vulnerabilities.

Keywords： glioma progression     molecular classification     EM/PM subtyping     intratumor heterogeneity    

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Thoughts on Scientific Issues in Engineering Material Research

yuqiao

Strategic Study of CAE 1999, Volume 1, Issue 3,   Pages 1-4

Abstract: Although some achievements have been accumulated in material research at home and abroad, deeper investigationsare still needed on a more precise model and state equation corresponding to the damage of a specific materialand the erosion of the space articles as well as the increase of the retreat value of the protection materialbelong to the response of materials to high speed collision.Electromagnetic materials such as radome material, infrared stealth material and EM shielding material are all EM functioning materials with EM wave of

Keywords： material for radome     wave absorbing material     infrared stealth material     EMC material    

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A novel approach to minimizing material loss for computer numerical control flank-regrinding of worn

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 3, doi: 10.1007/s11465-023-0757-z

Abstract: However, the traditional method involves material waste by trial and error and dramatically decreasesstudy presented a new approach to planning the wheel path for regrinding worn end mills to minimize materialResults showed that the proposed approach could save 25% of cutter material compared with the traditionalThis work effectively provides a general regrinding solution for the worn flank with maximum material-saving

Keywords： flank-regrinding     worn end mill     wheel position and orientation     material loss     over-cut    

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Title Author Date Type Operation

A multiscale material model for heterogeneous liquid droplets in solid soft composites

Journal Article

Heterogeneity of the tumor immune microenvironment and clinical interventions

Journal Article

Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and

Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang

Journal Article

Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype

Xu Chen, Xiaomao Xu, Fei Xiao

Journal Article

Selectively structural fractionation and economical-functionality conversion of lignocellulosic biomass

Chen Hongzhang,Qiu Weihua and Wang Lan

Journal Article

Computational modeling of fracture in concrete: A review

Luthfi Muhammad Mauludin, Chahmi Oucif

Journal Article

Analysis of stress and failure in rock specimens with closed and open flaws on the surface

Journal Article

Heterogeneous influence of individuals’ behavior on mask efficacy in gathering environments

Journal Article

Liquid metal material genome: Initiation of a new research track towards discovery of advanced energy

Lei WANG, Jing LIU

Journal Article

Robust topology optimization of multi-material lattice structures under material and load uncertainties

Yu-Chin CHAN, Kohei SHINTANI, Wei CHEN

Journal Article

State-of-the-Art Review of High-Throughput Statistical Spatial-Mapping Characterization Technology and Its Applications

Haizhou Wang, Lei Zhao, Yunhai Jia, Dongling Li, Lixia Yang, Yuhua Lu, Guang Feng, Weihao Wan

Journal Article

Factors affecting the distribution of microplastics in soils of China

Journal Article

Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

Journal Article

Thoughts on Scientific Issues in Engineering Material Research

yuqiao

Journal Article

A novel approach to minimizing material loss for computer numerical control flank-regrinding of worn

Journal Article